Image-guided cranial irradiation-induced ablation of dentate gyrus neurogenesis impairs extinction of recent morphine reward memories.

摘要: Dentate gyrus adult neurogenesis is implicated in the formation of hippocampal-dependent contextual associations. However, role during reward-based context-dependent paradigms-such as conditioned place preference (CPP)-is understudied. Therefore, we used image-guided, hippocampal-targeted X-ray irradiation (IG-IR) and morphine CPP to explore whether dentate plays a reward memories created C57BL/6J male mice. In addition, appears participate greater extent retrieval extinction recent ( 1 week posttraining) memories, specifically examined reward-associated probed at remote timepoints. Six weeks post-IG-IR or Sham treatment, mice underwent CPP. Using separate groups, was found be similar between IG-IR treatments. Interestingly, showed impaired extinction-or increased persistence-of morphine-associated memory when it 24-hr (recent) but not 3-weeks (remote) postconditioning relative Taken together, these data show that hippocampal-directed associated decrease affect persistence recently-but remotely-probed memory. These indicate novel for particularly rate memories. Consideration this work may lead better understanding extinction-based behavioral interventions psychiatric conditions characterized by dysregulated processing.