Within-Family Environmental Transmission of Drug Abuse: A Swedish National Study

摘要: Context Drug abuse (DA) strongly runs in families. Does this result solely from genetic factors or does the family environment contribute? Objective To determine familial environmental contribution to risk for DA. Design Follow-up 9 public databases (1961-2009) siblings and spouses. Setting Sweden. Participants A total of 137 199 sibling pairs 7561 spousal containing a proband with DA matched control probands. Main Outcome Measures recorded medical, legal, pharmacy registry records. Results In best-fit model, which contained significant linear, quadratic, cubic effects, among full DA, relative declined more than 6.0 born within 2 years each other less 4.5 when 10 apart. Controlling age differences pairs, hazard rate affected was older vs younger 1.42 (95% CI, 1.31-1.54). spouse 25.0 1 year registration after 5 years. Conclusions effects by examining only siblings, resemblance significantly greater closer distant age. Older transmitted their vice versa. After one is registered has large short-lived increase risk. These results support strong influences on at various life stages. complete understanding transmission will require knowledge how act interact over development.