Searching for the human genetic factors standing in the way of universally effective vaccines.

摘要: Vaccines have revolutionized modern public health. The effectiveness of some vaccines is limited by the variation in response observed between individuals and across populations. There compelling evidence that a significant proportion this variability can be attributed to human genetic variation, especially for those administered early life. Identifying understanding determinants could far-reaching influence upon future methods vaccine design deployment. In review, we summarize studies been undertaken attempting identify heterogeneity against hepatitis B, measles rubella. We offer critical appraisal these make series suggestions about how techniques, including genome-wide association studies, used characterize architecture heterogeneity. conclude suggesting findings from such translated improve target vaccination more cost-effective manner.