Role of G Protein β3 Subunit C825T and HLA Class II Polymorphisms in the Immune Response after HBV Vaccination
作者： Monika Lindemann , Vahé Barsegian , Winfried Siffert , Stanislav Ferencik , Michael Roggendorf
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摘要: Abstract The G protein β3 ( GNB3 ) subunit and HLA are candidate genes predictive of immune response capacity. We therefore studied the influence both gene systems on cellular humoral immunity against hepatitis B virus (HBV) in 79 HBV booster-vaccinated healthy volunteers an independent group 77 probands after basic immunization. Following booster vaccination, lymphocyte vitro proliferation stimulation with surface antigen was 2.5-fold increased 825T (TC + TT) vs CC allele carriers P = 0.01) not influenced by HLA-DRB1 or DQB1 alleles. In addition, anti-HBs antibody titers groups were 2-fold TC decreased TT carriers. However, immunization elevated HLA-DQB1*0301 corrected 0.027). summary, appears as a marker particularly responses following vaccination.
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