Analysis of HLA-DQB1 gene polymorphisms in asymptomatic HBV carriers and chronic hepatitis B patients in the Chinese Han population.
作者： Z. Xi-Lin , D. Te , L. Jun-Hong , L. Liang-Ping , G. Xin-Hui
DOI: 10.1111/J.1744-313X.2006.00607.X
关键词:
摘要: Summary Host genetic factors and environment including hepatitis B virus (HBV) genotype are widely viewed as common basis of the different outcomes HBV infection. Human leucocyte antigen (HLA) plays an important role in immunological reaction to infection. The study aimed explore whether HLA-DQB1 allele polymorphisms associated with infection Chinese Han population. One hundred thirty-four asymptomatic carriers 139 chronic patients were recruited this case-control Beijing, China. Sequence-specific primers–polymerase chain was used detect 13 alleles gene. The frequency distributions two groups analysed using sas 9.1.2 software. After adjustment confounders frequencies HLA-DQB1*0503 *0303 group statistically significant lower than those carrier (P = 0.04; P = 0.05), exposure alcohol consumption clearly higher that (P = 0.004). HLA-DQB1*0503 independently resistant B, is risk factor B.
sci-hub.se 参考文章(23)
Bin Gao, Interaction of alcohol and hepatitis viral proteins: implication in synergistic effect of alcohol drinking and viral hepatitis on liver injury Alcohol. ,vol. 27, pp. 69- 72 ,(2002) , 10.1016/S0741-8329(02)00201-X
Fu-Sheng Wang, Current status and prospects of studies on human genetic alleles associated with hepatitis B virus infection World Journal of Gastroenterology. ,vol. 9, pp. 641- 644 ,(2003) , 10.3748/WJG.V9.I4.641
J S Beaty, K A West, G T Nepom, Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1. Molecular and Cellular Biology. ,vol. 15, pp. 4771- 4782 ,(1995) , 10.1128/MCB.15.9.4771
Y. Fu, Z. Liu, J. Lin, Z. Jia, W. Chen, D. Pan, Y. Liu, Y. Zhu, R. Chen, A. Xu, HLA-DRB1, DQB1 and DPB1 polymorphism in the Naxi ethnic group of South-western China Tissue Antigens. ,vol. 61, pp. 179- 183 ,(2003) , 10.1034/J.1399-0039.2003.00012.X
Chloe L. Thio, Mary Carrington, Darlene Marti, Stephen J. O'Brien, David Vlahov, Kenrad E. Nelson, Jacquie Astemborski, David L. Thomas, Class II HLA alleles and hepatitis B virus persistence in African Americans. The Journal of Infectious Diseases. ,vol. 179, pp. 1004- 1006 ,(1999) , 10.1086/314684
M Muro, N Herrero, L Marin, A Torio, A Minguela, F Sanchez-Bueno, A. M. Garcia-Alonso, M. R. Alvarez-Lopez, Polymorphism in the upstream regulatory region of the HLA-DQB1 gene in liver graft recipients. Human Biology. ,vol. 73, pp. 845- 854 ,(2001) , 10.1353/HUB.2001.0088
B.E. Shaw, H. Maldonado, J.A. Madrigal, C. Smith, F. Petronzelli, N.P. Mayor, M.N. Potter, J.G. Bodmer, S.G.E. Marsh, Polymorphisms in the TNFA gene promoter region show evidence of strong linkage disequilibrium with HLA and are associated with delayed neutrophil engraftment in unrelated donor hematopoietic stem cell transplantation. Tissue Antigens. ,vol. 63, pp. 401- 411 ,(2004) , 10.1111/J.0001-2815.2004.00218.X
Andrea Baas, Xiaojiang Gao, G. Chelvanayagam, Peptide binding motifs and specificities for HLA-DQ molecules Immunogenetics. ,vol. 50, pp. 8- 15 ,(1999) , 10.1007/S002510050680
B Ferstl, T Zacher, B Lauer, N Blagitko-Dorfs, A Carl, R Wassmuth, Allele-specific quantification of HLA-DQB1 gene expression by real-time reverse transcriptase-polymerase chain reaction. Genes and Immunity. ,vol. 5, pp. 405- 416 ,(2004) , 10.1038/SJ.GENE.6364108
Rajendra Bhimma, Mike G. Hammond, Hoosen M. Coovadia, Mirriam Adhikari, Catherine A. Connolly, HLA class I and II in black children with hepatitis B virus-associated membranous nephropathy Kidney International. ,vol. 61, pp. 1510- 1515 ,(2002) , 10.1046/J.1523-1755.2002.00287.X