Host genetic factors in hepatitis B infection, liver cancer and vaccination response: a review with a focus on Africa.

摘要: The disease burden due to hepatitis B virus (HBV) infection remains significant; 350 million people are infected world-wide, and around half a deaths each year HBV-related liver hepatocellular carcinoma (HCC). Infant immunisation against was introduced in the early 1980s, vaccine is routinely administered across regions where endemic has been shown be safe effective. However, large number of older individuals with persistent means that will not reduced significantly for several decades. Furthermore, failure respond vaccination observed about 5% vaccinees date we have limited information on durability protection infection. Hepatitis pathogenesis known influenced by factors including host genetics factors. This review aims give an overview role genetic variation HBV development HCC. Vaccine-induced immunity is, at least part, heritable also discuss findings control responses vaccination. epidemiology differs world region, as does makeup originating from different regions. focuses situation Africa, highly endemic.