IL-17 and Th17 cells, key players in arthritis

摘要: IL-17 was identified in 1995/96 as a T cell-derived cytokine with effects on inflammation and neutrophil activation. Rheumatoid arthritis (RA) has emerged the best-studied situation to justify selection of therapeutic target. By interacting other proinflammatory cytokines, found induce bone cartilage destruction. In 2006, precise cell source mouse. These cells were named Th17, key role for these demonstrated various situations associated inflammation. new findings confirmed extended results previously obtained following identification cytokine. At same time, additional information members family structure receptor complex. Such knowledge further choice possible modalities control IL-17.