Bilateral subthalamic nucleus stimulation and quality of life in advanced Parkinson's disease.

摘要: We examined the impact of subthalamic nuclei (STN) deep brain stimulation (DBS) on health-related quality life (QoL) patients with advanced Parkinson's disease (PD). Seventeen consecutive refractory motor fluctuations and dyskinesia were included in study (mean age, 60.9 +/- 7.7 years [range, 43-74 years]; duration, 16.4 8.5 7-38 mean off-medication Hoehn Yahr stage, 4.23 0.66 2.5-5]). Each patient's assessment was carried out using common rating scales, following Core Assessment Program for Intracerebral Transplantation (CAPIT) protocol. Dyskinesia emotional state evaluated through Abnormal Involuntary Movement Scale (AIMS) Hospital Anxiety Depression (HAD). QoL assessed by means Disease Questionnaire Spanish version (PDQ-39). Significant benefit obtained manifestations complications disease, as well functional mood (P < 0.001). Some dimensions (mobility activities daily living) PDQ-39 Summary Index (PDQ-39SI) showed a significant improvement Benefit modest 0.05) three other domains (emotional well-being, stigma, bodily discomfort) nil rest. There no correlation between change variables. As measured PDQ-39, STN-DBS significantly improves important aspects PD.