Abnormal functional connectivity density in children with anisometropic amblyopia at resting-state.

摘要: Abstract Amblyopia is a developmental disorder resulting from anomalous binocular visual input in early life. Task-based neuroimaging studies have widely investigated cortical functional impairments amblyopia, but changes spontaneous neuronal activities amblyopia remain largely unknown. In the present study, connectivity density (FCD) mapping, an ultrafast data-driven method based on fMRI, was applied for first time to investigate connectivities during resting-state. We quantified and compared both short- long-range FCD brains of children with anisometropic (AAC) normal sighted (NSC). contrast NSC, AAC showed significantly decreased short-range inferior temporal/fusiform gyri, parieto-occipital rostrolateral prefrontal cortices, as well premotor cortex, dorsal parietal lobule, frontal-insular cortices. Furthermore, most regions reduced occipital posterior cortices AAC. The results suggest that chronically poor not only impairs brain׳s connections pathways frontal which important cognitive control, also affects among areas, subserve visuomotor visual-guided actions, visuospatial attention modulation integration salient information. This study provides evidence abnormal brain amblyopia.