Nonpulmonary Organ Dysfunction and Its Impact on Outcome in Patients With Acute Respiratory Failure

摘要: Purpose This study aimed to define the prevalence, severity, and progression of nonpulmonary organ dysfunction, its impact on outcome in patients with acute respiratory failure (ARF) at a ICU tertiary referral hospital northern India. Methods Daily patient data were collected 711 adult ARF calculate component total sequential assessment (SOFA) scores. Hospital survival was main measure. Multiple logistic regression modeling conducted assess contribution incremental dysfunction various systems mortality. Kaplan-Meier curves drawn temporal trends survival, group comparisons based log-rank test. Cox proportional hazard performed hazards earlier Discrimination evaluated using receiver operating characteristic (ROC) curves. Results Four hundred seventy-five (66.8%) had one or more dysfunctions admission. The overall mortality rate 33.9%. rates median declined steadily as number organs involved increased. Admission, maximum, ΔSOFA scores significantly higher nonsurvivors. Increasing baseline cardiovascular neurologic SOFA scores, corresponding associated progressively odds mortality, well increasing for after adjustment etiology failure. Maximum score best discriminator predicting (area under ROC curve, 0.767). Conclusion Baseline new-onset influences ARF.