A singleiv dose of ondansetron 8 mg prior to induction of anaesthesia reduces postoperative nausea and vomiting in gynaecological patients

摘要: The effect of a single intravenous dose ondansetron in preventing postoperative nausea and emesis (retching vomiting) (PONV) was investigated randomized, double-blind, placebo-controlled, multicentre, international study. Women ASA class I–III, requiring gynaecological laparotomy, vaginal hysterectomy, or major surgery were selected for Two hundred thirty-five received placebo, 231 1 mg ondansetron, 228 8 229 16 as an infusion over five minutes before the induction anaesthesia. A standardized balanced anaesthetic technique employed. This consisted premedication with either diazepam temazepam, thiopentone induction, maintenance nitrous oxide oxygen supplemented enflurane isoflurane, intraoperative analgesia fentanyl, neuromuscular blockade any choice agent reversal neostigmine atropine. Postoperative achieved morphine, prochlorperazine metoclopramide given if rescue antiemetic required. greater percentage patients groups experienced no (44% 39% respectively) than placebo (29% 28% first 24 hr period (8 vs mg: P ≤ 0.001; placebo: < 0.05; 0.05). Similarly, who did not experience 20%, 26%, 31% mg, treatment groups, respectively Overall, incidences adverse events similar. It is concluded that at doses both well tolerated effective emesis, benefit observed comparison dose.