Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats
作者： Yusuke Sato , Atsuko Honjo , Daisuke Ishikawa , Seiichi Nishizawa , Norio Teramae
DOI: 10.1039/C1CC11370D
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摘要: We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C–C mismatch present in hairpin structures (CCG)n trinucleotide repeats that are associated with neurological diseases; this is accompanied by significant fluorescence quenching ATMND.
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