High Glycemic Index Starch Promotes Hypersecretion of Insulin and Higher Body Fat in Rats without Affecting Insulin Sensitivity

摘要: In rats, prolonged feeding of high glycemic index (GI) starch results in basal hyperinsulinemia and an elevated insulin response to intravenous glucose tolerance test (IVGTT). The aim this study was assess hepatic peripheral resistance (IR) using euglycemic hyperinsulinemic clamps. Insulin sensitivity, epididymal fat deposition fasting leptin concentrations were compared rats fed isocalorically a low or GI diet for 7 wk (45% carbohydrate, 35% 20% protein as energy) (20% 59% 21% 4 so that final body weights similar. At the end study, had higher concentration mass than group, despite comparable weights. High both resulted during IVGTT, but impaired seen only fat. did not affect clamp uptake output, induced IR. findings suggest hypersecretion without IR may be one mechanism increased diets.