Short-term, high-fat diets lower circulating leptin concentrations in rats

摘要: Background: Leptin is produced in proportion to body fat mass and can act on the brain induce satiety regulate adipose tissue mass; factors other than may influence circulating leptin concentrations. Objective: We explored possibility that short-term, moderately high-fat diets weight gain by producing inappropriately low Design: Female Hooded Wistar rats were fed either a diet or control diet. Body weight, energy intake, composition, fasting plasma compared after 4 14 wk of dietary treatment. Results: After wk, abdominal was 38% greater those (P < 0.01). However, concentrations 24% lower animals 0.05), resulting significantly per unit 0.005). From gained twice as much consumed 32 kJ/d more controls (both P 0.05). At 27% = 0.058) there significant negative association between (r 0.44, Conclusions: In short term, associated with expected concentrations, which correlate higher weight. A therefore contribute reducing secretion tissue.