FIVE YEAR FOLLOW-UP OF TREATMENT WITH TRIHEXYPHENIDYL (ARTANE)

摘要: Four years ago, two of us (L. J. D. and K. C.) reported our observations during a year treating 117 patients with paralysis agitans (Parkinson's disease) trihexyphenidyl (Artane). 1 The salient findings were (1) the therapeutic effects equalled or surpassed those other agents in use at time (2) was relatively free from disturbing side-reactions. Other reports appeared quick succession corroborated most findings. Corbin 2 gratifying results 86 cases; Dow Rosenbaum 3 20 Canelis, Farnell, McGavack 4 23 Ellenbogen 5 12 Phillips, Montuschi, Sharkey 6 200 postencephalitic Salzer 7 Effron Denker 8 80 Shapiro 9 60 cases. Before long, drug came into professional throughout world, today it is commonly accepted as standby