Plasma Concentration of C-Reactive Protein and the Calculated Framingham Coronary Heart Disease Risk Score

作者: Michelle A Albert , Robert J Glynn , Paul M Ridker , None

DOI: 10.1161/01.CIR.0000080289.72166.CF

关键词:

摘要: Background— Although C-reactive protein (CRP) predicts vascular risk, few data are available evaluating the relation between CRP and Framingham Coronary Heart Disease Risk Score (FCRS). Methods Results— levels were compared with calculated 10-year FCRS in a cross-sectional survey of 1666 individuals free cardiovascular disease. Among men women not using hormone replacement therapy (HRT), significantly related to categories [total cholesterol (TC) score for women: r=0.29 r=0.22, respectively; LDL respectively, all probability values <0.01]. However, correlated minimally individual components FCRS, which included age (rmen=0.17, rwomen=−0.003), TC (rmen=−0.02, rwomen=−0.006), HDL-C (rmen=0.13), LDL-C (rmen=−0.0002, rwomen=0.012), blood pressure (rmen=0.18, rwomen=0.22), diabetes (rmen=0.10, rwomen=0.07), smoking (rmen=0.16, rwomen=0....

参考文章(21)
Mark Upton, Ann Rumley, Alex McConnachie, Denis O’Reilly, Graham Watt, Gordon Lowe, Different effects of oral and transdermal hormone replacement therapies on factor IX, APC resistance, t-PA, PAI and C-reactive protein--a cross-sectional population survey. Thrombosis and Haemostasis. ,vol. 86, pp. 550- 556 ,(2001) , 10.1055/S-0037-1616085
Wolfgang Koenig, Malte Sund, Margit Fröhlich, Hans-Günther Fischer, Hannelore Löwel, Angela Döring, Winston L. Hutchinson, Mark B. Pepys, C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men Results From the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992 Circulation. ,vol. 99, pp. 237- 242 ,(1999) , 10.1161/01.CIR.99.2.237
Keaven M. Anderson, Patricia M. Odell, Peter W.F. Wilson, William B. Kannel, Cardiovascular disease risk profiles American Heart Journal. ,vol. 121, pp. 293- 298 ,(1991) , 10.1016/0002-8703(91)90861-B
Michelle A Albert, Joan Staggers, Paul Chew, Paul M Ridker, PRINCE Investigators, None, The Pravastatin Inflammation CRP Evaluation (PRINCE): Rationale and design American Heart Journal. ,vol. 141, pp. 893- 898 ,(2001) , 10.1067/MHJ.2001.115297
Paul M Ridker, Charles H Hennekens, Julie E Buring, Nader Rifai, None, C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women New England Journal of Medicine. ,vol. 342, pp. 836- 843 ,(2000) , 10.1056/NEJM200003233421202
Mary Cushman, Elaine N. Meilahn, Bruce M. Psaty, Lewis H. Kuller, Adrian S. Dobs, Russell P. Tracy, Hormone Replacement Therapy, Inflammation, and Hemostasis in Elderly Women Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 19, pp. 893- 899 ,(1999) , 10.1161/01.ATV.19.4.893
Michelle A. Albert, Ellie Danielson, Nader Rifai, Paul M Ridker, for the PRINCE Investigators, Effect of Statin Therapy on C-Reactive Protein Levels JAMA. ,vol. 286, pp. 64- 70 ,(2001) , 10.1001/JAMA.286.1.64
John Danesh, Peter Whincup, Mary Walker, Lucy Lennon, Andrew Thomson, Paul Appleby, J Ruth Gallimore, Mark B Pepys, Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses BMJ. ,vol. 321, pp. 199- 204 ,(2000) , 10.1136/BMJ.321.7255.199
Ralph B. D'Agostino, Scott Grundy, Lisa M. Sullivan, Peter Wilson, , Validation of the Framingham Coronary Heart Disease Prediction Scores JAMA. ,vol. 286, pp. 180- 187 ,(2001) , 10.1001/JAMA.286.2.180