MECHANISM OF COLLAGEN RESORPTION IN REVERSIBLE HEPATIC FIBROSIS.

摘要: Abstract Collagen and bile ductular cells, which are rapidly formed during subacute ethionine intoxication, disappear speedily after replacement of by methionine. The half-life hepatic DNA was not shortened recovery, indicating that lack renewal rather than active catabolism accounts for the disappearance cells. By contrast, recovery collagen greatly reduced. Its susceptibility to collagenase trypsin increased, specific activity soluble rose, suggesting depolymerization denaturation collagen. It is suggested removal proliferated serve as a framework upon laid down, leads secondary changes in collagen, facilitating its removal.