Clinically important drug–drug interactions in primary care

摘要: SUMMARY What is known and Objective: Drug–drug interactions (DDIs) cause considerable morbidity mortality worldwide may lead to hospital admission. Sophisticated computerized drug information monitoring systems, more recently established in many of the emerging economies, including Malaysia, are capturing useful on prescribing. Our aim report an investigation potentially serious DDIs, using a university primary care–based system prescription records from its care services. Methods: We retrospectively collected data two academic years over 20 months databases at Universiti Sains Malaysia (USM) users USM Results Discussion: Three hundred eighty-six DDI events were observed cohort 208 exposed patients total 23 733 patients, representing 2-year period prevalence 876AE4 per 100 000 patients. Of 138 (66AE3%) one event, 29 (13AE9%) events, 15 (7AE2%) three 6 (2AE9%) four (9AE6%) than five events. Overall, increasing mean number episodes DDIs was noted among within age category ‡70 (P =0 AE01), trend medications prescribed <0 AE001) long-term therapeutic groups AE001). new Conclusion: describe clinically important economy setting identify common DDIs. In line with observations developed higher seen aged prescribed. The easiest method reduce frequency Therapeutic alternatives should be selected cautiously.