The frequency of adverse drug reaction related admissions according to method of detection, admission urgency and medical department specialty

作者: Miran Brvar , Nina Fokter , Matjaz Bunc , Martin Mozina

DOI: 10.1186/1472-6904-9-8

关键词:

摘要: Adverse Drug Reactions (ADRs) have been regarded as a major public health problem since they represent sizable percentage of admissions. Unfortunately, there is wide variation ADR related admissions among different studies. The aim this study was to evaluate the frequency and its dependency on reporting method detection, urgency included medical departments reflecting department/hospital type within one study. team internal medicine specialists retrospectively reviewed 520 randomly selected records (3%) patients treated in primary city tertiary referral governmental hospital for certain ADRs causing regarding WHO causality criteria. All were checked whether treating physicians recognised documented information system ensure diagnoses properly coded database national spontaneous searched with established due by same represented 5.8% all (30/520). detected employing computer-assisted approach using an ICD-10 coding 0.2% (1/520), no patient admitted reported (0/520). recognized also depends department's specialty (p = 0.001) acceptance urgently 0.001). Patients significantly older compared without 0.025). Gastrointestinal bleeding NSAID, acetylsalicylic acid warfarin most common that resulted admission 40% (12/30) according cause hospital. recognise criteria note them records, but rarely code report ADRs. detection method, department patients.

参考文章(27)
Consuelo Pedrós, Antoni Vallano, Gloria Cereza, Gemma Mendoza-Aran, Antònia Agustí, Cristina Aguilera, Immaculada Danés, Xavier Vidal, Josep M Arnau, None, An intervention to improve spontaneous adverse drug reaction reporting by hospital physicians: a time series analysis in Spain. Drug Safety. ,vol. 32, pp. 77- 83 ,(2009) , 10.2165/00002018-200932010-00007
A. Alvarez-Requejo, A. Carvajal, B. Bégaud, Y. Moride, T. Vega, L. H. Martín Arias, Under-reporting of adverse drug reactions. Estimate based on a spontaneous reporting scheme and a sentinel system. European Journal of Clinical Pharmacology. ,vol. 54, pp. 483- 488 ,(1998) , 10.1007/S002280050498
E. G. Brown, J. E. Harrison, Dictionaries and Coding in Pharmacovigilance John Wiley & Sons, Ltd. pp. 533- 557 ,(2005) , 10.1002/9780470975053.CH10
P. A. Routledge, M. S. O'Mahony, K. W. Woodhouse, Adverse drug reactions in elderly patients. British Journal of Clinical Pharmacology. ,vol. 57, pp. 121- 126 ,(2003) , 10.1046/J.1365-2125.2003.01875.X
I. Ralph Edwards, Cecilia Biriell, Harmonisation in pharmacovigilance. Drug Safety. ,vol. 10, pp. 93- 102 ,(1994) , 10.2165/00002018-199410020-00001
Jason Lazarou, Bruce H. Pomeranz, Paul N. Corey, Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-analysis of Prospective Studies JAMA. ,vol. 279, pp. 1200- 1205 ,(1998) , 10.1001/JAMA.279.15.1200
Patrick Waller, Mary Shaw, Davidson Ho, Saad Shakir, Shah Ebrahim, Hospital admissions for 'drug-induced' disorders in England: a study using the Hospital Episodes Statistics (HES) database. British Journal of Clinical Pharmacology. ,vol. 59, pp. 213- 219 ,(2005) , 10.1111/J.1365-2125.2004.02236.X
Cornelis S van der Hooft, Miriam C J M Sturkenboom, Kees van Grootheest, Herre J Kingma, Bruno H.Ch. Stricker, Adverse drug reaction-related hospitalisations: a nationwide study in The Netherlands. Drug Safety. ,vol. 29, pp. 161- 168 ,(2006) , 10.2165/00002018-200629020-00006
H. Dormann, A. Neubert, M. Criegee-Rieck, T. Egger, M. Radespiel-Troger, T. Azaz-Livshits, M. Levy, K. Brune, E.G. Hahn, Readmissions and adverse drug reactions in internal medicine: the economic impact. Journal of Internal Medicine. ,vol. 255, pp. 653- 663 ,(2004) , 10.1111/J.1365-2796.2004.01326.X
Munir Pirmohamed, Sally James, Shaun Meakin, Chris Green, Andrew K Scott, Thomas J Walley, Keith Farrar, B Kevin Park, Alasdair M Breckenridge, Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients BMJ. ,vol. 329, pp. 15- 19 ,(2004) , 10.1136/BMJ.329.7456.15