Mobilization of Cytogenetically ‘Normal’ Blood Progenitors Cells by Intensive Conventional Chemotherapy for Chronic Myeloid and Acute Lymphoblastic Leukemia

摘要: Various lines of evidence suggest that substantial numbers very primitive normal hematopoietic cells persist in the marrow most patients with CML, despite presence an expanded Philadelphia-Chromosome (Ph) positive population, and clones might, certain circumstances, have a proliferative advantage over leukemic populations. We recently demonstrated 5/8 CML blastic phase (BP) blood progenitor cells/(BPC) harvested during early recovery from aplasia were Ph-negative on cytogenetic analysis, suggesting leukapheresis may provide useful source 'normal' progenitors for subsequent reinfusions. report here update 40 Ph + 9 ALL first or relapses associated translocations including t(8;14) t(4;8) t(4;11) t(9;22). All these received intensive conventional chemotherapy aplasia, when WBC reached 0.5–2.0 × 109/L, BPC...