Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury

摘要: Traumatic brain injury (TBI) is associated with poor neurological outcome, including necrosis and edema. In this study, we investigated whether agmatine treatment reduces edema apoptotic cell death after TBI. TBI was produced by cold to the cerebral primary motor cortex of rats. Agmatine administered 30 min once daily until end experiment. Animals were sacrificed for analysis at 1, 2, or 7 days injury. Various analyses performed investigate disruption blood-brain barrier (BBB) dysfunction To examine extent TBI, expression aquaporins (AQPs), phosphorylation mitogen-activated protein kinases (MAPKs), nuclear translocation factor-κB (NF-κB) investigated. Our findings demonstrated that significantly suppressing AQP1, 4, 9. addition, reduced MAPKs increasing NF-κB These results suggest may have therapeutic potential neural in various central nervous system diseases.