Arginine rich coconut kernel protein modulates diabetes in alloxan treated rats

摘要: Diabetes mellitus is a syndrome characterized by the loss of glucose homeostasis due to several reasons. In spite presence known anti-diabetic medicines in pharmaceutical market, remedies from natural resources are used with success treat this disease. The present study was undertaken investigate effect coconut kernel protein (CKP) on alloxan induced diabetes Sprague-Dawley rats. injecting single dose (150mg/kg body weight) intraperitoneally. After inducing diabetes, purified CKP isolated dried administered rats along semi synthetic diet for 45 days. experimental period, serum glucose, insulin, activities different key enzymes involved metabolism, liver glycogen levels and histopathology pancreas were evaluated. amount individual amino acids also determined using HPLC. Results showed that has significant arginine. feeding attenuated increase insulin diabetic Glycogen carbohydrate metabolizing treated reverted back normal compared control. Histopathology revealed reduced related pancreatic damage These results clearly demonstrated potent activity which may be probably its β cell regeneration through