Obesity and metabolic complications: contribution of dehydroepiandrosterone and other steroid hormones

摘要: Obesity is a heterogeneous condition and not every obese patient at increased risk of cardiovascular diseases (CVD). It now well established that the regional distribution body fat critical correlate metabolic complications obesity. Studies have assessed adipose tissue by imaging techniques such as computed tomography demonstrated importance intra-abdominal (visceral) depot marker cluster abnormalities which include glucose intolerance, insulin resistance, hyper-insulinemia, hypertriglyceridemia, elevated number apo B-carrying lipoproteins hypoalphalipoproteinemia. Although association between visceral obesity can hardly be questioned, it has been suggested may necessarily represent causal relationship. For instance, concomitant alterations in sex steroid levels found both men women with abdominal also reported to significantly correlated resistant-dyslipidemic state subjects. In women, associated free testosterone concentrations reduced hormone binding globulin (SHBG) levels, whereas this adrenal C12 (dehydroepiandrosterone, androstenedione, androstene-3 beta, 17 beta-diol) decreased SHBG concentrations. These altered SHBG; independent correlates although they cannot solely account for CVD these patients. regard, intervention studies are clearly warranted better quantity respective contribution excess modulators disturbances increasing