Ribavirin in cancer immunotherapies: controlling nitric oxide augments cytotoxic lymphocyte function.
作者： Richard E. Kast
DOI: 10.1016/S1476-5586(03)80011-8
关键词:
摘要: Either ribavirin (RBV) or cyclophosphamide (CY) can shift an immune response from Th2 toward a Th1 cytokine profile. CY is used in this role various current cancer immunotherapy attempts but with mixed success. More potent and reliable immunoadjuvants biasing methods are needed. RBV today mainly to augment interferon-alpha treatment of hepatitis C. shifts more effectively than may be safe useful adjuvant for immunotherapeutic efforts. thought act by inhibition tetrahydrobiopterin synthesis. Tetrahydrobiopterin essential cofactor all known isoforms nitric oxide synthase. Lowered favors development as high levels favor weighting.
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