Temperature-dependent interferon-sensitivity of foot-and-mouth disease virus.

摘要: Several strains of foot-and-mouth disease virus (FMDV), types O, A, and C, grown in primary or secondary calf kidney cell cultures had an interferon-sensitivity which varied with incubation temperature. Some wild-type growing optimally at 37° C showed increased 28° C. Strain CL was more sensitive both infra- supraoptimal growth Temperature-sensitive mutants optimal replication were Interferon-sensitivity moreover greatly among the tested even Results are interpreted by hypothesis that depends on a specific product, presumably protein, reduced range function (compared virion formation) acts as “anti-interferon”. Possible relationships virulence FMDV temperature-sensitivity viral proteins discussed.