Synthesis, characterization and antimicrobial activities of water-soluble amphiphilic copolymers containing ciprofloxacin and quaternary ammonium salts
作者： Man He , Huining Xiao , Yuming Zhou , Peng Lu
DOI: 10.1039/C5TB00029G
关键词:
摘要: A series of novel water-soluble amphiphilic copolymers containing ciprofloxacin (CPF) and quaternary ammonium salts were prepared by the free-radical copolymerization methacrylate monomers with CPF, salt (QAS) butyl acrylate (BA). The characterized 1H-NMR, charge density UV measurements. antimicrobial activities copolymers, based on minimum inhibition concentration (MIC) against Escherichia coli (E. coli), varied hydrophobic BA content in copolymers. incorporation moiety further enhanced antibacterial reducing MIC to 4.0 ppm. UV260 absorption measurements applied reveal dynamic process results zones shaking flask methods antimicrobial-modified fibers showed that had excellent when cellulose fibers. In presence 2 wt% (based oven-dried fibers) copolymer, growth reached 100%.
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