Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials.
作者： M O Leach , K M Brindle , J L Evelhoch , J R Griffiths , M R Horsman
DOI: 10.1259/BJR/15917261
关键词:
摘要: MRI is increasingly being used to evaluate antiangio-genic and antivascular agents in early stage clinical trials.The measurement analysis methodology required forrobust application of such trials has beenconsidered by specialist panels a workshop, resultingin recommendations for the design trials,and identification areas requiring further development.The following document text poster presentedbyCancerResearchUKPharmacodynamic/PharmacokineticTechnologies Advisory Committee (PTAC) on use ofMRI evaluation antiangiogenic antivascularcancer drugs presented at American Association forCancer Research, Washington (2003) Inter-national Society Magnetic Resonance Medicine, 11thScientific meeting, Toronto, 2003 [1, 2].
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sussex.ac.uk参考文章(9)
Susan M. Galbraith, Ross J. Maxwell, Martin A. Lodge, Gillian M. Tozer, John Wilson, N. Jane Taylor, J. James Stirling, Luiza Sena, Anwar R. Padhani, Gordon J.S. Rustin, Combretastatin A4 Phosphate Has Tumor Antivascular Activity in Rat and Man as Demonstrated by Dynamic Magnetic Resonance Imaging Journal of Clinical Oncology. ,vol. 21, pp. 2831- 2842 ,(2003) , 10.1200/JCO.2003.05.187
Paul S. Tofts, Gunnar Brix, David L. Buckley, Jeffrey L. Evelhoch, Elizabeth Henderson, Michael V. Knopp, Henrik B.W. Larsson, Ting-Yim Lee, Nina A. Mayr, Geoffrey J.M. Parker, Ruediger E. Port, June Taylor, Robert M. Weisskoff, Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. Journal of Magnetic Resonance Imaging. ,vol. 10, pp. 223- 232 ,(1999) , 10.1002/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S
Jeffrey L. Evelhoch, Key factors in the acquisition of contrast kinetic data for oncology. Journal of Magnetic Resonance Imaging. ,vol. 10, pp. 254- 259 ,(1999) , 10.1002/(SICI)1522-2586(199909)10:3<254::AID-JMRI5>3.0.CO;2-9
Paul S. Tofts, Modeling tracer kinetics in dynamic Gd-DTPA MR imaging Journal of Magnetic Resonance Imaging. ,vol. 7, pp. 91- 101 ,(1997) , 10.1002/JMRI.1880070113
Axel Gossmann, Thomas H. Helbich, Nagato Kuriyama, S. Ostrowitzki, Timothy P.L. Roberts, David M. Shames, N. van Bruggen, Michael F. Wendland, Mark A. Israel, Robert C. Brasch, Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to anti-angiogenic therapy in a xenograft model of glioblastoma multiforme. Journal of Magnetic Resonance Imaging. ,vol. 15, pp. 233- 240 ,(2002) , 10.1002/JMRI.10072
G. C. Jayson, J. Zweit, A. Jackson, C. Mulatero, P. Julyan, M. Ranson, L. Broughton, J. Wagstaff, L. Hakannson, G. Groenewegen, J. Bailey, N. Smith, D. Hastings, J. Lawrance, H. Haroon, T. Ward, A. T. McGown, M. Tang, D. Levitt, S. Marreaud, F. F. Lehmann, M. Herold, H. Zwierzina, Molecular Imaging and Biological Evaluation of HuMV833 Anti-VEGF Antibody: Implications for Trial Design of Antiangiogenic Antibodies Journal of the National Cancer Institute. ,vol. 94, pp. 1484- 1493 ,(2002) , 10.1093/JNCI/94.19.1484
Susan M. Galbraith, Gordon J.S. Rustin, Martin A. Lodge, N. Jane Taylor, J. James Stirling, Michael Jameson, Paul Thompson, David Hough, Lindsey Gumbrell, Anwar R. Padhani, Effects of 5,6-Dimethylxanthenone-4-Acetic Acid on Human Tumor Microcirculation Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Journal of Clinical Oncology. ,vol. 20, pp. 3826- 3840 ,(2002) , 10.1200/JCO.2002.09.144
Bruno Morgan, Anne L Thomas, Joachim Drevs, Juergen Hennig, Martin Buchert, Asvina Jivan, Mark A Horsfield, Klauss Mross, Howard A Ball, Lucy Lee, William Mietlowski, Stefan Fuxius, Clemens Unger, Ken O’Byrne, Andrew Henry, Graham R Cherryman, Dirk Laurent, Margaret Dugan, Dieter Marmé, William P Steward, None, Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Biomarker for the Pharmacological Response of PTK787/ZK 222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, in Patients With Advanced Colorectal Cancer and Liver Metastases: Results From Two Phase I Studies Journal of Clinical Oncology. ,vol. 21, pp. 3955- 3964 ,(2003) , 10.1200/JCO.2003.08.092
J C Waterton, G Jayson, A Padhani, M Horsman, PM Price, D McIntyre, M O Leach, K M Brindle, M V Knopp, G M Tozer, PS Tofts, P Workman, R Rathbone, A Jackson, J L Evelhoch, W Vennart, G Rustin, SR Williams, R J Maxwell, I R Judson, J R Griffiths, Assessment of anti-angiogenic and anti-vascular therapeutics using Magnetic Resonance Imaging: recommendations for appropriate methodology for clinical trials. ,(2003)