MicroRNA-134 suppresses endometrial cancer stem cells by targeting POGLUT1 and Notch pathway proteins.
作者： Yongtao Gao , Te Liu , Yongyi Huang
DOI: 10.1016/J.FEBSLET.2014.12.002
关键词:
摘要: We aimed to ascertain the role of microRNAs (miRNAs) in regulating human endometrial cancer stem cells (HuECSCs). The expression level miRNA-134 (miR-134), a member DLK1-DIO3 genomic imprinted miRNA cluster, differed significantly between HuECSCs and (HuECCs). miR-134 inhibited proliferation migration by targeting protein O-glucosyltransferase 1 (POGLUT1) expression. Exogenous overexpression downregulated POGLUT1 Notch pathway proteins vitro. affected G2/M phase suppressed growth xenograft tumours formed. Thus, endogenous regulation may suppress tumourigenesis carcinoma.
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febsletters.org 参考文章(30)
Ruopeng Zha, Weijie Guo, Zhenfeng Zhang, Zhaoping Qiu, Qifeng Wang, Jie Ding, Shenglin Huang, Taoyang Chen, Jianren Gu, Ming Yao, Xianghuo He, Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin β1 in hepatocellular carcinoma. PLOS ONE. ,vol. 9, ,(2014) , 10.1371/JOURNAL.PONE.0087665
Melih Acar, Hamed Jafar-Nejad, Hideyuki Takeuchi, Akhila Rajan, Dafina Ibrani, Nadia A. Rana, Hongling Pan, Robert S. Haltiwanger, Hugo J. Bellen, Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling Cell. ,vol. 132, pp. 247- 258 ,(2008) , 10.1016/J.CELL.2007.12.016
Daniel J. Moloney, Louisa H. Shair, Frederick M. Lu, Jie Xia, Robert Locke, Khushi L. Matta, Robert S. Haltiwanger, Mammalian Notch1 Is Modified with Two Unusual Forms ofO-Linked Glycosylation Found on Epidermal Growth Factor-like Modules Journal of Biological Chemistry. ,vol. 275, pp. 9604- 9611 ,(2000) , 10.1074/JBC.275.13.9604
TE LIU, WEIWEI CHENG, YONGTAO GAO, HUI WANG, ZHIXUE LIU, Microarray analysis of microRNA expression patterns in the semen of infertile men with semen abnormalities. Molecular Medicine Reports. ,vol. 6, pp. 535- 542 ,(2012) , 10.3892/MMR.2012.967
S.-P. Lin, P. Coan, S. T. da Rocha, H. Seitz, J. Cavaille, P.-W. Teng, S. Takada, A. C. Ferguson-Smith, Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region. Development. ,vol. 134, pp. 417- 426 ,(2007) , 10.1242/DEV.02726
Q. Chu, L. Liu, W. Wang, Overexpression of hCLP46 enhances Notch activation and regulates cell proliferation in a cell type-dependent manner. Cell Proliferation. ,vol. 46, pp. 254- 262 ,(2013) , 10.1111/CPR.12037
Qian Zhang, Joseph Celestino, Rosemarie Schmandt, Adrienne S. McCampbell, Diana L. Urbauer, Larissa A. Meyer, Jennifer K. Burzawa, Marilyn Huang, Melinda S. Yates, David Iglesias, Russell R. Broaddus, Karen H. Lu, Chemopreventive effects of metformin on obesity-associated endometrial proliferation American Journal of Obstetrics and Gynecology. ,vol. 209, pp. 241- 2412 ,(2013) , 10.1016/J.AJOG.2013.03.008
Evangelos Briasoulis, Leonidas Benetatos, Eleftheria Hatzimichael, Eric Londin, George Vartholomatos, Phillipe Loher, Isidore Rigoutsos, The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis Cellular and Molecular Life Sciences. ,vol. 70, pp. 795- 814 ,(2013) , 10.1007/S00018-012-1080-8
Robin G. Lerner, Claudia Petritsch, A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions Nature Cell Biology. ,vol. 16, pp. 212- 214 ,(2014) , 10.1038/NCB2924
Te Liu, Yongyi Huang, Jianjun Liu, Yanhui Zhao, Lizhen Jiang, Qin Huang, Weiwei Cheng, Lihe Guo, MicroRNA-122 influences the development of sperm abnormalities from human induced pluripotent stem cells by regulating TNP2 expression. Stem Cells and Development. ,vol. 22, pp. 1839- 1850 ,(2013) , 10.1089/SCD.2012.0653