Metabolic Suppression by 3-Iodothyronamine Induced Muscle Cell Atrophy via Activation of FoxO–Proteasome Signaling and Downregulation of Akt1–S6K Signaling

作者: Hyunwoo Ju , Taewan Kim , Chan-Moon Chung , Junsoo Park , Takeshi Nikawa

DOI: 10.1248/BPB.B16-00653

关键词:

摘要: … We observed that the oxygen consumption rate of C2C12 … deiodination and decarboxylation of thyroxine (T4). This compound is … On 5 d after differentiation of C2C12 cells, the myotubes …

参考文章(32)
J.A. Haviland, H. Reiland, D.E. Butz, M. Tonelli, W.P. Porter, R. Zucchi, T.S. Scanlan, G. Chiellini, F.M. Assadi-Porter, NMR-based metabolomics and breath studies show lipid and protein catabolism during low dose chronic T1 AM treatment Obesity. ,vol. 21, pp. 2538- 2544 ,(2013) , 10.1002/OBY.20391
Jeffrey J. Widrick, Robert H. Fitts, Danny R. Riley, Functional and structural adaptations of skeletal muscle to microgravity The Journal of Experimental Biology. ,vol. 204, pp. 3201- 3208 ,(2001) , 10.1242/JEB.204.18.3201
Rashmi Mullur, Yan-Yun Liu, Gregory A. Brent, Thyroid Hormone Regulation of Metabolism Physiological Reviews. ,vol. 94, pp. 355- 382 ,(2014) , 10.1152/PHYSREV.00030.2013
Scott K. Powers, Michael P. Wiggs, Jose A. Duarte, A. Murat Zergeroglu, Haydar A. Demirel, Mitochondrial signaling contributes to disuse muscle atrophy. American Journal of Physiology-endocrinology and Metabolism. ,vol. 303, ,(2012) , 10.1152/AJPENDO.00609.2011
Alessia Peserico, Fulvio Chiacchiera, Valentina Grossi, Antonio Matrone, Dominga Latorre, Marta Simonatto, Aurora Fusella, James G. Ryall, Lydia W. S. Finley, Marcia C. Haigis, Gaetano Villani, Pier Lorenzo Puri, Vittorio Sartorelli, Cristiano Simone, A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels Cellular and Molecular Life Sciences. ,vol. 70, pp. 2015- 2029 ,(2013) , 10.1007/S00018-012-1244-6
S. L. J. Wijers, W. H. M. Saris, W. D. van Marken Lichtenbelt, Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity. Obesity Reviews. ,vol. 10, pp. 218- 226 ,(2009) , 10.1111/J.1467-789X.2008.00538.X
Joong-Gon Kim, Young-Kyu Song, Ye-Hyun Jo, Mi-Ran Yu, Hyun-Woo Ju, In-Ho Choi, Chan-Moon Chung, A New Efficient Synthetic Method for 3-Iodothyronamine Involving Sonication and its Potent Hypothermic Efficacy Bulletin of The Korean Chemical Society. ,vol. 32, pp. 1131- 1132 ,(2011) , 10.5012/BKCS.2011.32.4.1131
Thomas S Scanlan, Katherine L Suchland, Matthew E Hart, Grazia Chiellini, Yong Huang, Paul J Kruzich, Sabina Frascarelli, Dane A Crossley, James R Bunzow, Simonetta Ronca-Testoni, Emil T Lin, Daniel Hatton, Riccardo Zucchi, David K Grandy, 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nature Medicine. ,vol. 10, pp. 638- 642 ,(2004) , 10.1038/NM1051
Hyunwoo Ju, Hyekyoung So, Kyungbong Ha, Kyoungsook Park, Ju-Woon Lee, Chan-Moon Chung, Inho Choi, Sustained torpidity following multi‐dose administration of 3‐iodothyronamine in mice Journal of Cellular Physiology. ,vol. 226, pp. 853- 858 ,(2011) , 10.1002/JCP.22573
Claire C. Bastie, Zaher Nahlé, Thomas McLoughlin, Karyn Esser, Wenwei Zhang, Terry Unterman, Nada A. Abumrad, FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms. Journal of Biological Chemistry. ,vol. 280, pp. 14222- 14229 ,(2005) , 10.1074/JBC.M413625200