Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity.

摘要: Large inter-individual differences in cold-induced (non-shivering) and diet-induced adaptive thermogenesis exist animals humans. These energy expenditure can have a large impact on long-term balance thus body weight (when other factors remain stable). Therefore, the level of might relate to susceptibility obesity; efforts increase be used treat obesity. In small mammals, main process involved is mitochondrial uncoupling brown adipose tissue (BAT), which regulated by sympathetic nervous system. For long time, it was assumed that not major physiological contributor adult However, several studies conducted recent years suggest BAT skeletal muscle humans physiologically significant. Other mechanisms besides are futile calcium cycling, protein turnover substrate cycling. conjunction with advances signal transduction studies, this knowledge makes manipulation more realistic option pharmacologically interesting target