White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

摘要: Living in an enriched environment with complex physical and social stimulation leads to improved cognitive metabolic health. In white fat, enrichment induced the upregulation of brown fat cell fate determining gene Prdm16, fat-specific markers, genes involved thermogenesis β-adrenergic signaling. Moreover, pockets cells prototypical morphology high UCP1 levels were observed mice associated resistance diet-induced obesity. Hypothalamic overexpression BDNF reproduced enrichment-associated activation program lean phenotype. Inhibition signaling by genetic knockout or dominant-negative trkB reversed this Our pharmacologic data suggest a mechanism whereby induction hypothalamic expression response environmental stimuli selective sympathoneural modulation induce "browning" increased energy dissipation.