A Protocol for Housing Mice in an Enriched Environment.

摘要: Environmental enrichment (EE) is a housing environment for mice that boosts mental and physical health compared to standard laboratory housing. Our recent studies demonstrate environmental decreases adiposity, increases energy expenditure, resists diet induced obesity, causes cancer remission inhibition in mice. EE typically consists of larger living space, variety ‘toys’ interact with, running wheels, can include number other novel changes. All this fosters more complex social engagement, cognitive stimulations. Importantly, the toy location type changed regularly, which encourages adapt frequently changing environment. Many variables be manipulated promote effects Thus these approaches are difficult control must properly managed successfully replicate associated phenotypes. Therefore, goal video how set up maintained assure complex, challenging, controlled so researchers easily reproduce protective against obesity cancer.