Coping with Stress During Aging: The Importance of a Resilient Brain

摘要: Background Resilience is the ability to achieve a positive outcome when we are in face of adversity. It supposes an active resistance adversity by coping mechanisms which genetic, molecular, neural and environmental factors involved. has been usually studied early ages few known about it during aging. Methods In this review, will address age-related changes brain involved regulating stress response. Furthermore, using EE paradigm, analyse resilient potential intervention its neurobiological basis. case, focus on identifying characteristics (modifications HPA structure function, neurogenesis, specific neuron types, glia, neurotrophic factors, nitric oxide synthase or microRNAs, among others). Results The evidence suggests that healthy lifestyle crucial role promote Along with behavioral described, better regulation axis, enhanced levels postmitotic type-3 cells GABAergic neurotransmission some resilience. Conclusion Future research should identify different biomarkers increase develop mood disorders based knowledge, new therapeutic targets.