Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrum

摘要: Intrahepatic cholangiocarcinoma, second in incidence to hepatocellular carcinoma among the primary liver carcinomas, has an even more dismal prognosis. cholangiocarcinoma is difficult diagnose at early stage of development and advances aggressively, with widespread metastases. Molecular genetic features intrahepatic have been partially elucidated, although specific lesions molecular processes that drive its development, progression, metastasis are still obscure. Evidence accumulated from many sources suggesting components a spectrum including poorly aberrantly differentiated varieties. Primary carcinomas arise cells different stages encompass entire lineage epithelial generated hepatoblasts and/or adult stem cells, share critical genomic aberrations phenotypes these progenitor cells.