Inactivation of human arylamine N-acetyltransferase 1 by hydrogen peroxide and peroxynitrite.
作者： Jean‐Marie Dupret , Julien Dairou , Noureddine Atmane , Fernando Rodrigues‐Lima
DOI: 10.1016/S0076-6879(05)00012-1
关键词:
摘要: Arylamine N‐acetyltransferases (NAT) are xenobiotic‐metabolizing enzymes responsible for the acetylation of many arylamine and heterocyclic amines. They therefore play an important role in detoxification activation numerous drugs carcinogens. Two closely related isoforms (NAT1 NAT2) have been described humans. NAT2 is present mainly liver intestine, whereas NAT1 found a wide range tissues. Interindividual variations NAT genes shown to be potential source pharmacological and/or pathological susceptibility. Evidence now shows that redox conditions may also contribute overall activity. This chapter summarizes current knowledge on human regulation by reactive oxygen nitrogen species.
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