Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

摘要: Objective. To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review quantitative studies. Data Sources. MEDLINE was searched using keywords related to “endothelial cells” “endothelium” and, for different categories, respectively, “smoking”; “blood pressure”; “diabetes mellitus” or “insulin resistance”; “dyslipidemia”; “aging” “elderly”; “angina pectoris” “myocardial infarction”; “stroke” “cerebrovascular disease”; “homocysteine”; “C-reactive protein”; “vitamin D”. Study Selection. Database hits were evaluated against explicit inclusion criteria. From 927 database hits, 43 studies included. Syntheses. EPC count has been suggested risk estimation clinical practice, since it is currently accepted that EPCs can work as proangiogenic support cells, maintaining their importance regenerative/reparative potential, also prognostic markers. Conclusions. showed an important role identifying conditions, suggest evaluation predictor outcomes appears be reasonable defined settings. Due capability proliferation, circulation, development functional progeny, great interest directed therapeutic use atherosclerotic diseases. This trial registered with registration number: Prospero CRD42015023717.