Histamine increases venular permeability via a phospholipase C-NO synthase-guanylate cyclase cascade
作者： Y. Yuan , H. J. Granger , D. C. Zawieja , D. V. DeFily , W. M. Chilian
DOI: 10.1152/AJPHEART.1993.264.5.H1734
关键词:
摘要: In this study, we hypothesized that histaminergic increases in venular permeability result from a cascade triggered by activation of phospholipase C (PLC), inducing the synthesis nitric oxide (NO) and activating guanylate cyclase. The apparent coefficient to albumin (Pa) was measured isolated porcine coronary venules subjected constant flow hydrostatic oncotic pressures. Histamine (2.5, 5, 10 microM) transiently progressively increased Pa. PLC inhibitor 2-nitro-4-carboxyphenyl N,N-diphenylcarbamate (NCDC; 100 decreased baseline abolished effect histamine. NO synthase NG-monomethyl-L-arginine (L-NMMA; cyclase 6-anilinoquinoline-5,8-quinone (LY 83583; also blocked histamine-induced hyperpermeability. L-Arginine (3 mM) reversed inhibition L-NMMA. NG-monomethyl-D-arginine did not influence Furthermore, sodium nitroprusside (10 augmented Pa two- threefold; presence LY 83583 but altered NCDC. results suggest histamine direct action on endothelial cells through PLC-NO synthase-guanylate cyclase-signaling cascade.
sci-hub.se 参考文章(28)
F. E. Curry, W. L. Joyner, J. C. Rutledge, Graded modulation of frog microvessel permeability to albumin using ionophore A23187. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 258, ,(1990) , 10.1152/AJPHEART.1990.258.2.H587
Serine esterase inhibitors block stimulus-induced mobilization of arachidonic acid and phosphatidylinositide-specific phospholipase C activity in platelets. Journal of Biological Chemistry. ,vol. 255, pp. 6024- 6027 ,(1980) , 10.1016/S0021-9258(18)43692-7
J J Lynch, T J Ferro, F A Blumenstock, A M Brockenauer, A B Malik, Increased endothelial albumin permeability mediated by protein kinase C activation. Journal of Clinical Investigation. ,vol. 85, pp. 1991- 1998 ,(1990) , 10.1172/JCI114663
Masaki Nakane, Jane Mitchell, Ulrich Förstermann, Ferid Murad, Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase Biochemical and Biophysical Research Communications. ,vol. 180, pp. 1396- 1402 ,(1991) , 10.1016/S0006-291X(05)81351-8
Bruce H. Lipton, Klaus G. Bensch, Marvin A. Karasek, Histamine-modulated transdifferentiation of dermal microvascular endothelial cells Experimental Cell Research. ,vol. 199, pp. 279- 291 ,(1992) , 10.1016/0014-4827(92)90436-C
William G. Mayhan, Role of nitric oxide in modulating permeability of hamster cheek pouch in response to adenosine 5′-diphosphate and bradykinin Inflammation. ,vol. 16, pp. 295- 305 ,(1992) , 10.1007/BF00917622
Yasutomi Nishizuka, The role of protein kinase C in cell surface signal transduction and tumour promotion Nature. ,vol. 308, pp. 693- 698 ,(1984) , 10.1038/308693A0
C. L. CHANDER, A. R. MOORE, F. M. DFSA, D. HOWAT, D. A. WILLOUGHBY, The local modulation of vascular permeability by endothelial cell derived products. Journal of Pharmacy and Pharmacology. ,vol. 40, pp. 745- 746 ,(2011) , 10.1111/J.2042-7158.1988.TB07011.X
Ferenc Joó, Péter Temesvári, Ernö Dux, Regulation of the macromolecular transport in the brain microvessels: the role of cyclic GMP. Brain Research. ,vol. 278, pp. 165- 174 ,(1983) , 10.1016/0006-8993(83)90235-4
Rob Leurs, Marion M. Brozius, Wilco Jansen, Aalt Bast, Hendrik Timmerman, Histamine H1-receptor-mediated cyclic GMP production in guinea-pig lung tissue is an L-arginine-dependent process. Biochemical Pharmacology. ,vol. 42, pp. 271- 277 ,(1991) , 10.1016/0006-2952(91)90713-F