Integrated analysis identified genes associated with a favorable prognosis in oligodendrogliomas.
作者： Yanwei Liu , Huimin Hu , Chuanbao Zhang , Zheng Wang , Mingyang Li
DOI: 10.1002/GCC.22323
关键词:
摘要: Oligodendrogliomas (ODs) are the second most common malignant brain tumor and exhibit characteristic co-deletion of chromosomal arms 1p 19q (co-deletion 1p/19q), which is associated with down-regulation suppressors. However, 1p/19q indicates a favorable prognosis that cannot be explained by In present study, we determined was reduced Ki-67 protein level based on analysis 354 ODs. To identify genes codeletion 1p/19q, analyzed 96 ODs RNA-sequencing 136 4 normal tissue samples RNA microarrays. We thus identified seven within significantly expression in compared to intact 1p/19q. A significant positive correlation observed between these candidate mRNA 305 gliomas 5 samples. Survival confirmed prognostic value genes. This finding suggests low provides novel therapeutic targets.
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