Correlation of IDH1 Mutation with Clinicopathologic Factors and Prognosis in Primary Glioblastoma: A Report of 118 Patients from China

摘要: It has been reported that IDH1 (IDH1R132) mutation was a frequent genomic alteration in grade II and III glial tumors but rare primary glioblastoma (pGBM). To elucidate the frequency of its clinical significance Chinese patients with pGBM, one hundred eighteen pGBMs were assessed by pyro-sequencing for status, results correlated characteristics molecular pathological factors. mutations detected 19/118 pGBM cases (16.1%). Younger age, methylated MGMT promoter, high expression mutant P53 protein, low Ki-67 or EGFR protein significantly status. Most notably, we identified mainly involved frontal lobe when compared those wild-type IDH1. In addition, Kaplan-Meier survival analysis revealed highly significant association between better outcome (p = 0.026 progression-free survival; p = 0.029 overall survival). However, our further multivariable regression analysis, independent prognostic effect is limited considering preoperative KPS score, extent resection, TMZ chemotherapy, levels, which might narrow power population future.