Restoring p53-Dependent Tumor Suppression

摘要: p53 represents an ideal target for anti-cancer drug design, because is mutated in more than half of human tumors. Most the remaining tumors, although carrying wild-type p53, have defects p53-mediated apoptotic pathway. Activation activity by either chemotherapy or radiotherapy induces p53-dependent apoptosis tumor cells with p53. Supplying exogenous cancer gene delivery effective suppressing growth both mutant and Blockage degradation pathways overexpression ARF interrupt MDM:p53 interaction inducing triggered cell death. Since unlike most other suppressor genes, over expressed cells, a promising approach involves restoring tumor-suppressing function to The restorable based on fact that PAb421 antibody against carboxy-terminus peptides corresponding p5...