Low Pass Genomes of 141,431 Chinese Reveal Patterns of Viral Infection, Novel Phenotypic Associations, and the Genetic History of China
作者： Siyang Liu , Shujia Huang , Fang Chen , Lijian Zhao , Yuying Yuan
DOI: 10.2139/SSRN.3188420
关键词:
摘要: We analyze whole-genome sequencing data from 141,431 Chinese women generated for non-invasive pregnancy testing (NIPT). use these to characterize the population genetic structure of China, and investigate associations with maternal infectious traits. discover that present day distribution alleles is a function both ancient migration recent movements. reveal novel phenotype-genotype associations, including several replicated height BMI, an association between age variant near EMB, twin NRG1. Finally, we identify unique pattern circulating viral DNA in plasma high prevalence hepatitis B other clinically relevant infections. A GWAS infections identifies exceptionally strong integrated herpesvirus 6 MOV10L1, which affects piRNA processing PIWI protein function. These findings demonstrate great value potential accumulating NIPT worldwide medical analyses.
sci-hub.st 参考文章(67)
S Altschula, Warren Gisha, Webb Millerb, E Meyersc, D Lipmana, None, Basic Local Alignment Search Tool Journal of Molecular Biology. ,vol. 215, pp. 403- 410 ,(1990) , 10.1016/S0022-2836(05)80360-2
William J. Astle, Heather Elding, Tao Jiang, Dave Allen, Dace Ruklisa, Alice L. Mann, Daniel Mead, Heleen Bouman, Fernando Riveros-Mckay, Myrto A. Kostadima, John J. Lambourne, Suthesh Sivapalaratnam, Kate Downes, Kousik Kundu, Lorenzo Bomba, Kim Berentsen, John R. Bradley, Louise C. Daugherty, Olivier Delaneau, Kathleen Freson, Stephen F. Garner, Luigi Grassi, Jose Guerrero, Matthias Haimel, Eva M. Janssen-Megens, Anita Kaan, Mihir Kamat, Bowon Kim, Amit Mandoli, Jonathan Marchini, Joost H.A. Martens, Stuart Meacham, Karyn Megy, Jared O’Connell, Romina Petersen, Nilofar Sharifi, Simon M. Sheard, James R. Staley, Salih Tuna, Martijn van der Ent, Klaudia Walter, Shuang-Yin Wang, Eleanor Wheeler, Steven P. Wilder, Valentina Iotchkova, Carmel Moore, Jennifer Sambrook, Hendrik G. Stunnenberg, Emanuele Di Angelantonio, Stephen Kaptoge, Taco W. Kuijpers, Enrique Carrillo-de-Santa-Pau, David Juan, Daniel Rico, Alfonso Valencia, Lu Chen, Bing Ge, Louella Vasquez, Tony Kwan, Diego Garrido-Martín, Stephen Watt, Ying Yang, Roderic Guigo, Stephan Beck, Dirk S. Paul, Tomi Pastinen, David Bujold, Guillaume Bourque, Mattia Frontini, John Danesh, David J. Roberts, Willem H. Ouwehand, Adam S. Butterworth, Nicole Soranzo, The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease Cell. ,vol. 167, pp. 1415- 1429.e19 ,(2016) , 10.1016/J.CELL.2016.10.042
, A global reference for human genetic variation. Nature. ,vol. 526, pp. 68- 74 ,(2015) , 10.1038/NATURE15393
Nicola Barban, Rick Jansen, Ronald De Vlaming, Ahmad Vaez, Jornt J Mandemakers, Felix C Tropf, Xia Shen, James F Wilson, Daniel I Chasman, Ilja M Nolte, Vinicius Tragante, Sander W Van Der Laan, John RB Perry, Augustine Kong, BIOS consortium, Tarunveer S Ahluwalia, Eva Albrecht, Laura Yerges-Armstrong, Gil Atzmon, Kirsi Auro, Kristin Ayers, Andrew Bakshi, Danny Ben-Avraham, Klaus Berger, Aviv Bergman, Lars Bertram, Lawrence F Bielak, Gyda Bjornsdottir, Marc Jan Bonder, Linda Broer, Minh Bui, Caterina Barbieri, Alana Cavadino, Jorge E Chavarro, Constance Turman, Maria Pina Concas, Heather J Cordell, Gail Davies, Peter Eibich, Nicholas Eriksson, Tõnu Esko, Joel Eriksson, Fahimeh Falahi, Janine F Felix, Mark Alan Fontana, Lude Franke, Ilaria Gandin, Audrey J Gaskins, Christian Gieger, Erica P Gunderson, Xiuqing Guo, Caroline Hayward, Chunyan He, Edith Hofer, Hongyan Huang, Peter K Joshi, Stavroula Kanoni, Robert Karlsson, Stefan Kiechl, Annette Kifley, Alexander Kluttig, Peter Kraft, Vasiliki Lagou, Cecile Lecoeur, Jari Lahti, Ruifang Li-Gao, Penelope A Lind, Tian Liu, Enes Makalic, Crysovalanto Mamasoula, Lindsay Matteson, Hamdi Mbarek, Patrick F McArdle, George McMahon, S Fleur W Meddens, Evelin Mihailov, Mike Miller, Stacey A Missmer, Claire Monnereau, Peter J van der Most, Ronny Myhre, Mike A Nalls, Teresa Nutile, Ioanna Panagiota Kalafati, Eleonora Porcu, Inga Prokopenko, Kumar B Rajan, Janet Rich-Edwards, Cornelius A Rietveld, Antonietta Robino, Lynda M Rose, Rico Rueedi, Kathleen A Ryan, Yasaman Saba, Daniel Schmidt, Jennifer A Smith, Lisette Stolk, Elizabeth Streeten, Anke Tönjes, Gudmar Thorleifsson, Sheila Ulivi, Juho Wedenoja, Juergen Wellmann, Peter Willeit, Jie Yao, Loic Yengo, Jing Hua Zhao, Wei Zhao, Daria V Zhernakova, Najaf Amin, Howard Andrews, Beverley Balkau, Nir Barzilai, Sven Bergmann, Ginevra Biino, Hans Bisgaard, Klaus Bønnelykke, Dorret I Boomsma, Julie E Buring, Harry Campbell, Stefania Cappellani, Marina Ciullo, Simon R Cox, Francesco Cucca, Daniela Toniolo, George Davey-Smith, Ian J Deary, George Dedoussis, Panos Deloukas, Cornelia M van Duijn, Eco JC de Geus, Johan G Eriksson, Denis A Evans, Jessica D Faul, Cinzia Felicita Sala, Philippe Froguel, Paolo Gasparini, Giorgia Girotto, Hans-Jörgen Grabe, Karin Halina Greiser, Patrick JF Groenen, Hugoline G de Haan, Johannes Haerting, Tamara B Harris, Andrew C Heath, Kauko Heikkilä, Albert Hofman, Georg Homuth, Elizabeth G Holliday, John Hopper, None, Genome-wide analysis identifies 12 loci influencing human reproductive behavior Nature Genetics. ,vol. 48, pp. 1462- 1472 ,(2016) , 10.1038/NG.3698
Joanne M. Britto, Sherralee Lukehurst, Renae Weller, Chris Fraser, Yubin Qiu, Paul Hertzog, Samantha J. Busfield, Generation and Characterization of Neuregulin-2-Deficient Mice Molecular and Cellular Biology. ,vol. 24, pp. 8221- 8226 ,(2004) , 10.1128/MCB.24.18.8221-8226.2004
Matthew T Buckley, Fernando Racimo, Morten E Allentoft, Majken K Jensen, Anna Jonsson, Hongyan Huang, Farhad Hormozdiari, Martin Sikora, Davide Marnetto, Eleazar Eskin, Marit E Jørgensen, Niels Grarup, Oluf Pedersen, Torben Hansen, Peter Kraft, Eske Willerslev, Rasmus Nielsen, None, Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes. Molecular Biology and Evolution. ,vol. 34, pp. 1307- 1318 ,(2017) , 10.1093/MOLBEV/MSX103
Latarsha J Carithers, Helen M Moore, None, The Genotype-Tissue Expression (GTEx) Project Biopreservation and Biobanking. ,vol. 13, pp. 307- 308 ,(2015) , 10.1089/BIO.2015.29031.HMM
Maxim C.-J. Cheeran, James R. Lokensgard, Mark R. Schleiss, Neuropathogenesis of Congenital Cytomegalovirus Infection: Disease Mechanisms and Prospects for Intervention Clinical Microbiology Reviews. ,vol. 22, pp. 99- 126 ,(2009) , 10.1128/CMR.00023-08
Jieming Chen, Houfeng Zheng, Jin-Xin Bei, Liangdan Sun, Wei-hua Jia, Tao Li, Furen Zhang, Mark Seielstad, Yi-Xin Zeng, Xuejun Zhang, Jianjun Liu, None, Genetic Structure of the Han Chinese Population Revealed by Genome-wide SNP Variation American Journal of Human Genetics. ,vol. 85, pp. 775- 785 ,(2009) , 10.1016/J.AJHG.2009.10.016