Vasodilatory effect of ghrelin, an endogenous peptide from the stomach.
作者： Hiroyuki Okumura , Noritoshi Nagaya , Mitsunobu Enomoto , Eiichiroh Nakagawa , Hideo Oya
DOI: 10.1097/00005344-200206000-00001
关键词:
摘要: Summary: Ghrelin is a novel growth hormone (GH)-releasing peptide, isolated from the stomach, which identified as an endogenous ligand for GH secretagogues receptor. Although both ghrelin and its specific receptor are expressed in blood vessels, cardiovascular effects of remain unknown. To clarify whether has vasodilatory effect humans, response forearm flow (FBF) to intra-arterial infusion was examined eight healthy volunteers using plethysmograph. In addition, hormonal responses were studied. increased FBF dose-dependent manner. Pretreatment with NG-monomethyl-l-arginine (l-NMMA), nitric oxide synthase inhibitor, did not inhibit ghrelin, although l-NMMA significantly inhibited release. Serum insulin-like factor-I (IGF-I) level altered by administration. Plasma cyclic guanosine 3´,5´-monophosphate level, second messenger oxide, also altered. These results suggest that possibly through GH/IGF-I/nitric oxide–independent mechanisms.
sci-hub.se 参考文章(12)
Noritoshi Nagaya, Masayasu Kojima, Masaaki Uematsu, Masakazu Yamagishi, Hiroshi Hosoda, Hideo Oya, Yujiro Hayashi, Kenji Kangawa, Hemodynamic and hormonal effects of human ghrelin in healthy volunteers American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 280, ,(2001) , 10.1152/AJPREGU.2001.280.5.R1483
Yukari Date, Masamitsu Nakazato, Noboru Murakami, Masayasu Kojima, Kenji Kangawa, Shigeru Matsukura, Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochemical and Biophysical Research Communications. ,vol. 280, pp. 904- 907 ,(2001) , 10.1006/BBRC.2000.4212
Andrew D Howard, Scott D Feighner, Doris F Cully, Joseph P Arena, Paul A Liberator, Charles I Rosenblum, Michel Hamelin, Donna L Hreniuk, Oksana C Palyha, Jennifer Anderson, Philip S Paress, Carmen Diaz, Michael Chou, Ken K Liu, Karen Kulju McKee, Sheng-Shung Pong, Lee-Yuh Chaung, Alex Elbrecht, Mike Dashkevicz, Robert Heavens, Mike Rigby, Dalip JS Sirinathsinghji, Dennis C Dean, David G Melillo, Arthur A Patchett, Ravi Nargund, Patrick R Griffin, Julie A DeMartino, Sunil K Gupta, James M Schaeffer, Roy G Smith, Lex HT Van der Ploeg, None, A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release Science. ,vol. 273, pp. 974- 977 ,(1996) , 10.1126/SCIENCE.273.5277.974
Romano Deghenghi, Marco M. Cananzi, Antonio Torsello, Claudia Battisti, Eugenio E. Muller, Vittorio Locatelli, GH-releasing activity of hexarelin, a new growth hormone releasing peptide, in infant and adult rats Life Sciences. ,vol. 54, pp. 1321- 1328 ,(1994) , 10.1016/0024-3205(94)00510-9
Antonello E. Rigamonti, Silvano G. Cella, Nicoletta Marazzi, Eugenio E. Müller, Nitric oxide modulation of the growth hormone—releasing activity of hexarelin in young and old dogs Metabolism. ,vol. 48, pp. 176- 182 ,(1999) , 10.1016/S0026-0495(99)90030-6
Motoyuki Nakamura, Hiroaki Yoshida, Shinji Makita, Naoshi Arakawa, Hiroyuki Niinuma, Katsuhiko Hiramori, Potent and Long-Lasting Vasodilatory Effects of Adrenomedullin in Humans Comparisons Between Normal Subjects and Patients With Chronic Heart Failure Circulation. ,vol. 95, pp. 1214- 1221 ,(1997) , 10.1161/01.CIR.95.5.1214
R J Cody, F B Müller, S H Kubo, H Rutman, D Leonard, Identification of the direct vasodilator effect of milrinone with an isolated limb preparation in patients with chronic congestive heart failure. Circulation. ,vol. 73, pp. 124- 129 ,(1986) , 10.1161/01.CIR.73.1.124
Yutaka Masuda, Tsuguhiko Tanaka, Norio Inomata, Norio Ohnuma, Shoji Tanaka, Zen Itoh, Hiroshi Hosoda, Masayasu Kojima, Kenji Kangawa, Ghrelin stimulates gastric acid secretion and motility in rats. Biochemical and Biophysical Research Communications. ,vol. 276, pp. 905- 908 ,(2000) , 10.1006/BBRC.2000.3568
R H Böger, C Skamira, S M Bode-Böger, G Brabant, A von zur Muhlen, J C Frolich, Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. A double-blind, placebo-controlled study. Journal of Clinical Investigation. ,vol. 98, pp. 2706- 2713 ,(1996) , 10.1172/JCI119095
M Kelm, Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine-NO pathway. Cardiovascular Research. ,vol. 41, pp. 765- 772 ,(1999) , 10.1016/S0008-6363(98)00259-4