Synthesis and properties of degradable poly(vinyl alcohol) hydrogel

作者: Congming Xiao , Gaoyan Zhou

DOI: 10.1016/S0141-3910(03)00100-9

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摘要: Abstract A novel degradable hydrogel has been prepared by condensing poly(vinyl alcohol) (PVA) with ELDA, a diacid derived from lactic acid. The structure of the ELDA crosslinking agent and crosslinked PVA–ELDA polymer characterized FTIR. glass transition temperature (Tg) PVA–ELDA, determined DSC, is found to increase crosslink ratio (CR). character water in was also examined which shows that can be classified as bound free water. percentage CR 0.0151, 0.0101 0.0050 87.7, 74.5 76.4% respectively. maximum equilibrium content 123%. After 3-day's immersion phosphate-buffer saline (PBS) (0.1M, pH 7.4) at 37 °C, weight loss about 12.5%, indicates it degradable.

参考文章(26)
A. Grosse-Sommer, M. In, R. K. Prud'Homme, Degradable alkoxide-crosslinked hydrogels Journal of Polymer Science Part A. ,vol. 34, pp. 1447- 1453 ,(1996) , 10.1002/(SICI)1099-0518(199606)34:8<1447::AID-POLA8>3.0.CO;2-X
Byeongmoon Jeong, Sung Wan Kim, You Han Bae, Thermosensitive sol-gel reversible hydrogels. Advanced Drug Delivery Reviews. ,vol. 54, pp. 37- 51 ,(2002) , 10.1016/S0169-409X(01)00242-3
Shuichi Matsumura, Noriyasu Tomizawa, Atsuko Toki, Kimihito Nishikawa, Kazunobu Toshima, Novel Poly(vinyl alcohol)-Degrading Enzyme and the Degradation Mechanism Macromolecules. ,vol. 32, pp. 7753- 7761 ,(1999) , 10.1021/MA990727B
St�phane J. Carlotti, Olivia Giani-Beaune, Fran�ois Schu�, Characterization and mechanical properties of water-soluble poly(vinyl alcohol) grafted with lactic acid and glycolic acid Journal of Applied Polymer Science. ,vol. 80, pp. 142- 147 ,(2001) , 10.1002/1097-4628(20010411)80:2<142::AID-APP1082>3.0.CO;2-4
Akihiko Kikuchi, Teruo Okano, Pulsatile drug release control using hydrogels. Advanced Drug Delivery Reviews. ,vol. 54, pp. 53- 77 ,(2002) , 10.1016/S0169-409X(01)00243-5
W.E Hennink, C.F van Nostrum, Novel crosslinking methods to design hydrogels Advanced Drug Delivery Reviews. ,vol. 54, pp. 13- 36 ,(2002) , 10.1016/S0169-409X(01)00240-X