Expression of the stem cell markers CD133 and nestin in pancreatic ductal adenocarcinoma and clinical relevance
作者： Jong-Tae Park , Hyun-Jong Kim , Jung-Chul Kim , Kyung-Tae Kim , Seon-Young Yoo
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摘要: Background: To evaluate the prognostic implication of cancer stem cell markers in pancreac ductal adenocarcinoma (PDAC), expression CD133 and nestin were investigated a series PDAC patients relation to survival rate. Methods: This included 42 cases evaluated detected by immunohistochemistry. The presence immunopositive tumor cells considering intensity area was interpreted comparison patients’ clinicopathological data. Results: Twenty eight (66.7%) showed high expression. mainly identified apical border cell, but aberrant cytoplasmic or perinuclear location also noted. High found only 2 cases, along perinuerial stromal region 15 (35.7%). There no correlation between CD133, gemcitabine resistance. Statistically significant difference patient N stage (p=0.007), (p= 0.014) univariate analysis. Nestin wan not statistically significant, it helpful identify perineurial invasion. In Cox-regression hazard model stratified age sex for multivariable analysis, AJCC independent factors overall survival. Conclusions: is upregulated that related poor prognosis, treatment targeted positive cancer/cancer might be promising therapeutic strategy this patients.
参考文章(34)
David W. Hedley, Sylvia S. W. Ng, Ming-Sound Tsao, Sue Chow, Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells. Cancer Research. ,vol. 60, pp. 5451- 5455 ,(2000)
Fred Fandrich, Ole Ammerpohl, Holger Kalthoff, Monika Olempska, Patricia Alice Eisenach, Hendrik Ungefroren, Detection of tumor stem cell markers in pancreatic carcinoma cell lines. Hepatobiliary & Pancreatic Diseases International. ,vol. 6, pp. 92- ,(2007)
Kyung-Jung Kim, Kyung-Hwa Lee, Hyung-Seok Kim, Kyung-Sub Moon, Tae-Young Jung, Shin Jung, Min-Cheol Lee, The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas. Neuropathology. ,vol. 31, pp. 494- 502 ,(2011) , 10.1111/J.1440-1789.2010.01194.X
Masao Kawamoto, Toshiyuki Ishiwata, Kazumitsu Cho, Eiji Uchida, Murray Korc, Zenya Naito, Takashi Tajiri, Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer. Human Pathology. ,vol. 40, pp. 189- 198 ,(2009) , 10.1016/J.HUMPATH.2008.02.022
Hyung-Seok Kim, Hyung-Roul Youm, Ji-Shin Lee, Kyung-Whan Min, Jae-Hun Chung, Chang-Soo Park, Correlation between cyclooxygenase-2 and tumor angiogenesis in non-small cell lung cancer. Lung Cancer. ,vol. 42, pp. 163- 170 ,(2003) , 10.1016/S0169-5002(03)00290-3
Enza Lonardo, Patrick C. Hermann, Christopher Heeschen, Pancreatic cancer stem cells - update and future perspectives Molecular Oncology. ,vol. 4, pp. 431- 442 ,(2010) , 10.1016/J.MOLONC.2010.06.002
Urban Lendahl, Lyle B. Zimmerman, Ronald D.G. McKay, CNS stem cells express a new class of intermediate filament protein. Cell. ,vol. 60, pp. 585- 595 ,(1990) , 10.1016/0092-8674(90)90662-X
Denis Corbeil, Katja Roper, Christine A. Fargeas, Angret Joester, Wieland B. Huttner, Prominin: a story of cholesterol, plasma membrane protrusions and human pathology. Traffic. ,vol. 2, pp. 82- 91 ,(2001) , 10.1034/J.1600-0854.2001.020202.X
Wei-hui Liu, Ren Li, Ke-feng Dou, Convenient and Efficient Enrichment of the CD133+ Liver Cells from Rat Fetal Liver Cells as a Source of Liver Stem/Progenitor Cells Stem Cell Reviews and Reports. ,vol. 7, pp. 94- 102 ,(2011) , 10.1007/S12015-010-9119-4
YH Wang, F Li, B Luo, XH Wang, HC Sun, S Liu, YQ Cui, XX Xu, None, A side population of cells from a human pancreatic carcinoma cell line harbors cancer stem cell characteristics. Neoplasma. ,vol. 56, pp. 371- 378 ,(2009) , 10.4149/NEO_2009_05_371