MECHANISMS IN ENDOCRINOLOGY: Impact of isolated TSH levels in and out of normal range on different tissues.

摘要: Routine treatment of thyroid cancer (TC) includes long-term suppression TSH. The necessity this in low- and intermediate-risk patients as well the extent TSH is currently under discussion. A literature search was performed to illustrate role extrathyroidal cells identify potential reasons for different effects exogenously suppressed endogenously low levels. Although adverse subnormal supranormal blood levels on heart brain have not been consistently found, studies show a clear negative effect bone mineral density. Experimental data also support an important immune system. ability levothyroxine (l-T4) regulate triiodothyronine physiological manner limited. Reduction circadian changes levels, decrease hormone-binding proteins, prevention compensatory increases (e.g., old age), unresponsiveness TSH-producing TRH l-T4 might cause In view aggressive suppression, achieving suggested between 0.9 1 mU/l low-to-intermediate risk TC appears justified.