GPR35 Is a Target of the Loop Diuretic Drugs Bumetanide and Furosemide
作者： Yuhua Yang , Angela Fu , Xiaosu Wu , Jeff D. Reagan
DOI: 10.1159/000335127
关键词:
摘要: We report that the loop diuretic drugs bumetanide and furosemide used in treatment of hypertension are GPR35 agonists. utilized calcium flux, inositol phosphate accumulation, dynamic redistribution assays to examine pharmacology these compounds on human, mouse rat GPR35. While potent human GPR35, neither nor were active against or Furthermore, Na(+)-Cl(-) cotransporter inhibi- tors chlorothiazide hydrochlorothiazide inactive all three species. also demonstrate is expressed skin where it has been shown diuretics inhibit histamine-induced flare itch response. These findings suggest may play an important role cell biology be a potential target for variety immune disorders.
karger.com 
sci-hub.se 参考文章(15)
Laura Jenkins, Elisa Alvarez-Curto, Kate Campbell, Sabrina de Munnik, Meritxell Canals, Sabine Schlyer, Graeme Milligan, Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα13 and β-arrestin-2 British Journal of Pharmacology. ,vol. 162, pp. 733- 748 ,(2011) , 10.1111/J.1476-5381.2010.01082.X
Sabrina Bauer, Markus Neumeier, Josef Wanninger, Roland Walter, Andrea Kopp, Margarita Bala, Andreas Schäffler, Christa Buechler, Systemic resistin is increased in type 2 diabetic patients treated with loop diuretics Journal of Diabetes and Its Complications. ,vol. 25, pp. 377- 381 ,(2011) , 10.1016/J.JDIACOMP.2011.06.001
Graeme Milligan, Orthologue selectivity and ligand bias: translating the pharmacology of GPR35. Trends in Pharmacological Sciences. ,vol. 32, pp. 317- 325 ,(2011) , 10.1016/J.TIPS.2011.02.002
Jinghong Wang, Nicole Simonavicius, Xiaosu Wu, Gayathri Swaminath, Jeff Reagan, Hui Tian, Lei Ling, Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35 Journal of Biological Chemistry. ,vol. 281, pp. 22021- 22028 ,(2006) , 10.1074/JBC.M603503200
Antonio Foresi, Massimo Siffredi, Berardino Mastropasqua, Andrea Pelucchi, Marina Chiesa, Luigi Marazzini, Effect of Inhaled Furosemide and Cromolyn on Bronchoconstriction Induced by Ultrasonically Nebulized Distilled Water in Asthmatic Subjects Annals of Allergy Asthma & Immunology. ,vol. 78, pp. 238- 243 ,(1997) , 10.1016/S1081-1206(10)63395-9
R MELO, D SOLE, C NASPITZ, Comparative efficacy of inhaled furosemide and disodium cromoglycate in the treatment of exercise-induced asthma in children The Journal of Allergy and Clinical Immunology. ,vol. 99, pp. 204- 209 ,(1997) , 10.1016/S0091-6749(97)70097-6
Hiroyuki Ohshiro, Hiroko Tonai-Kachi, Katsuomi Ichikawa, GPR35 is a functional receptor in rat dorsal root ganglion neurons Biochemical and Biophysical Research Communications. ,vol. 365, pp. 344- 348 ,(2008) , 10.1016/J.BBRC.2007.10.197
Yuhua Yang, Jenny Ying-Lin Lu, Xiaosu Wu, Shamin Summer, John Whoriskey, Christiaan Saris, Jeff D. Reagan, G-Protein-Coupled Receptor 35 Is a Target of the Asthma Drugs Cromolyn Disodium and Nedocromil Sodium Pharmacology. ,vol. 86, pp. 1- 5 ,(2010) , 10.1159/000314164
Yasuhito Taniguchi, Hiroko Tonai-Kachi, Katsuhiro Shinjo, Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. FEBS Letters. ,vol. 580, pp. 5003- 5008 ,(2006) , 10.1016/J.FEBSLET.2006.08.015
Anchalee Yuengsrigul, Terry W. Chin, Eliezer Nussbaum, Immunosuppressive and cytotoxic effects of furosemide on human peripheral blood mononuclear cells. Annals of Allergy Asthma & Immunology. ,vol. 83, pp. 559- 566 ,(1999) , 10.1016/S1081-1206(10)62870-0