Temporal Patterns of Cocaine Use in Pregnancy

摘要: Seventy-five cocaine-using women enrolled in a comprehensive perinatal care program were divided into two groups: those who used cocaine only the first trimester of pregnancy (group 1 [N = 23]) and throughout 2 52]). Perinatal outcomes these pregnancies compared with matched group obstetric patients no history or evidence substance abuse 3 40]). Group had an increased rate preterm delivery low-birth-weight infants as well intrauterine growth retardation. rates complications similar to drug-free group. Mean birth weight, length, head circumference for term reduced infants. However, both groups cocaine-exposed demonstrated significant impairment orientation, motor, state regulation behaviors on Neonatal Behavioral Assessment Scale. ( JAMA 1989;261:1741-1744)