Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis.

摘要: Abstract Ethnopharmacological relevance Necrotizing enterocolitis (NEC) is the most important gastrointestinal emergency affecting especially preterm infants and causes severe morbidities mortality. However, there no cure. Oxidant stress, inflammation, apoptosis, as well prematurity are believed to responsible in pathogenesis of disease. Ginger its compounds have anti-inflammatory, antimicrobial, anti-oxidant properties immunomodulatory, cytoprotective/regenerative actions. Aim study This aimed evaluate beneficial effects ginger on intestinal damage an experimental rat model NEC. Materials methods Thirty newborn Wistar rats were divided into three groups: NEC, NEC + ginger control this study. was induced by injection intraperitoneal lipopolysaccharide, feeding with enteral formula, hypoxia-hyperoxia cold stress exposure. The pups group orally administered at a dose 1000 mg/kg/day. Proximal colon ileum excised. Histopathological, immunohistochemical (TUNEL for caspase 3 8) biochemical assays including xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malonaldehyde (MDA) myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), interleukin1β (IL-1β), interleukin 6 (IL-6) activity evaluated. Results Compared group, had better clinical disease scores weight gain (p  Conclusion therapy efficiently ameliorated severity may be promising treatment option.