trans-Cinnamaldehyde mitigated intestinal inflammation induced by Cronobacter sakazakii in newborn mice.

摘要: Necrotizing enterocolitis (NEC) is a serious intestinal disease associated with high mortality (40–60%) in newborn infants. Cronobacter sakazakii an important factor for NEC. However, studies regarding NEC pathogenesis and therapeutic treatments are still limited. Here, C. sakazakii-induced mouse neonatal inflammation model was employed to determine the effects of trans-cinnamaldehyde (TC) on infections. TC treatment reduced number colony-forming units ileal tissues mitigated morphological damage tissues. Additionally, it mRNA transcription inflammatory genes production interleukin 6 tumor necrosis factor-α mice infected sakazakii. Moreover, suppressed caspase-3 activity, modulated enterocyte apoptosis, inhibited nuclear factor-kappa B signaling pathway activation induced by These findings suggest that has protective murine may be potential agent preventing