Occult hepatitis B virus infection: a covert operation.

摘要: Detection of occult hepatitis B requires assays the highest sensitivity and specificity with a lower limit detection less than 10 IU/mL for virus (HBV) DNA <0.1 ng/mL surface antigen (HBsAg). This covert condition is relatively common in patients chronic C (HCV) that seems to exert some influence on replicative capacity latency HBV. virus-specific nucleic acid does not always translate into infectivity, occurrence primer-generated HBV partial genomic length immunocompetent individuals who have significant levels antibody (anti-HBs) may be biologically relevant. Acute flares alanine aminotransferase (ALT) occur during early phase therapy HCV or ALT remain elevated at end biochemical nonresponders should prompt an assessment B. Similarly, plasma from core (anti-HBc) positive (+/-anti-HBs <100 mIU/mL) examined most sensitive assay available. If liver biopsy available, immunostaining (HBsAg) (HBcAg) contemplated portion sample tested DNA. another reason optimal collection specimen (e.g. two passes 16-guage needle under ultrasound guidance). Transmission immunosuppressed orthotopic transplant recipients by donors (OHB) will continue occupy interests hepatologist. As OHB detectable serum, peripheral blood mononuclear cells (PBMC) and/or can reactivated following immunosuppression intensive cytotoxic chemotherapy, patient needs either monitored treated depending pretreatment serological results such as isolated anti-HBc reaction